Trans-omic analysis reveals opposite metabolic dysregulation between feeding and fasting in liver associated with…

According to a recent study published on ScienceDirect.com, trans-omic analysis has revealed opposite metabolic dysregulation between feeding and fasting in the liver. This finding sheds light on the intricate mechanisms that govern metabolic processes in the body.

The liver plays a crucial role in maintaining metabolic homeostasis by regulating glucose and lipid metabolism. During feeding, the liver processes nutrients and stores them for later use. However, during fasting, the liver mobilizes stored energy to provide fuel for the body. The study found that the metabolic pathways involved in these processes are regulated in an opposite manner.

Through a comprehensive analysis of transcriptomic, proteomic, and metabolomic data, the researchers identified key genes, proteins, and metabolites that are differentially expressed during feeding and fasting. This trans-omic approach allowed them to gain a holistic view of the metabolic changes occurring in the liver.

One of the major findings of the study was the upregulation of pathways related to lipogenesis and glycolysis during feeding, while pathways related to fatty acid oxidation and gluconeogenesis were upregulated during fasting. This opposing regulation ensures that the liver can efficiently switch between energy storage and mobilization depending on the body’s needs.

Furthermore, the researchers identified several transcription factors that play a key role in regulating these metabolic processes. They found that these transcription factors act as master regulators of gene expression, coordinating the expression of multiple genes involved in metabolic pathways.

The study also highlighted the importance of circadian rhythms in the regulation of liver metabolism. The researchers observed that many metabolic pathways in the liver follow a diurnal pattern, with peak activity during feeding and reduced activity during fasting. This suggests that the body has evolved to anticipate changes in nutrient availability and adjust its metabolic processes accordingly.

Overall, the findings of this study provide valuable insights into the complex interplay of genes, proteins, and metabolites that govern liver metabolism. By understanding the mechanisms underlying these processes, researchers hope to develop new therapies for metabolic disorders such as obesity and diabetes.